Publications | Drug Discovery Unit

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Feb 2012

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Publication Date:
01 Feb 2012

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Jan 2012

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors.

Publication Date:
12 Jan 2012

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Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Publication Date:
02 Jan 2012

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Dec 2011

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Publication Date:
09 Dec 2011

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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Publication Date:
07 Dec 2011

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Oct 2011

Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.

Publication Date:
13 Oct 2011

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Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Publication Date:
04 Oct 2011

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Mining the ChEMBL Database: An Efficient Chemoinformatics Workflow for Assembling an Ion Channel-Focused Screening Library

Publication Date:
03 Oct 2011

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Feb 2011

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Publication Date:
01 Feb 2011

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Jan 2011

Target validation: linking target and chemical properties to desired product profile.

Publication Date:
01 Jan 2011

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Finding new hits in neglected disease projects: target or phenotypic based screening?

Publication Date:
01 Jan 2011

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Dec 2010

Acetazolamide-based fungal chitinase inhibitors.

Publication Date:
01 Dec 2010

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Nov 2010

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.

Publication Date:
01 Nov 2010

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Oct 2010

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Publication Date:
15 Oct 2010

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Jul 2010

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Publication Date:
01 Jul 2010

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