University of Dundee, its Drug Discovery Unit ("DDU"), and Corbin Therapeutics ("Corbin") are pleased to announce their collaboration agreement to screen and identify small molecules capable of efficiently inhibiting a well-conserved ubiquitin-specific protease, USP15.
Corbin focuses on a novel therapeutic approach to treat various inflammatory disorders via USP15 inhibition. Recently published in Nature Immunology [(2017) 18:54–63], this protease is central in the neuro-inflammation pathology and its inhibition might be key preventing and treating inflammatory-based diseases, such as multiple sclerosis.
DDU has expanded its drug discovery capabilities towards a unique collaborative model, which maximizes the translation of life sciences research into therapeutic applications. The DDU works with partners across a wide variety of disciplines, including high-throughput screening, DMPK, medicinal chemistry, bioinformatics and computational drug design.
Dr. Maxime Ranger, President and Chief Executive Officer of Corbin, commented, "We are very pleased to make this alliance with DDU, where both combine their complementary expertise into novel target validation and efforts to identify promising inhibitors of USP15." Professor Paul Wyatt, Head of the DDU, added, "The DDU is committed to working collaboratively with partners, such as Corbin, to develop potential drug targets for diseases of unmet clinical need. We look forward to developing a productive partnership on this exciting target"